Chemotherapeutic Studies on Schistosomiasis and Clinical Epidemiological and Immunological Studies on Malaria in Amazonas, Brazil, Along the Ituxi River.
Abstract
Objectives are to find new prophylactic and curative drugs for the prevention and cure of schistosomiasis infections and to study the clinical, epidemiologic, drug susceptibility and vector transmission patterns of falciparum malaria in the Amazon River basin of Brazil. Both are primary diseases which would be acquired by US Military and DOD personnel in the event of deployment to any of numerous tropical areas. Prophylactic (PMT) and curative (PCT) testing (in mice) against schistosomiasis for candidate compounds submitted by the WRAIR Anti-Schistosomal Drug Testing Program. Compounds active in the primary screen are extensively reexamined for confirmation and dose response patterns. The malaria immunology studies include the testing of sera from endemic areas by the indirect fluroescent antibody test, in vitro drug susceptibility testing and creation of a cryobank of human strains of Plasmodium falciparum. Malaria vector transmission studies include field and laboratory analysis of morphological, behavioral, physiological and DDT susceptibility patterns of Anopheles darlingi and other potential anophelene malaria vector. During the reporting period 1065 compounds were screened in the PCT and PMT. Of these 58 were designated as confirmed or unconfirmed active and 232 were designated toxic.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1979
- Accession Number
- ADA098308
Entities
People
- Aluizio R. Prata
- Donald R. Roberts
- K. Mills Mcneil
- Willis A. Reid Jr.
Organizations
- University of BrasÃlia