The Role of Electronically Excited States and Free Radicals in Ultraviolet-Induced Lens Opacification.

Abstract

Ocular lens safety criteria with respect to UV radiation wavelength and dosage are outlined. These criteria are based on spectroscopic and biochemical studies of UV-exposed and control lenses as well as isolated lens proteins. Excited states of tryptophan in the lens crystallin proteins are implicated as the major species responsible for UV-induced cataractogenesis; possible causal mechanisms including crosslinking of peptides are suggested. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1980
Accession Number
ADA098650

Entities

People

  • Bill S. Yamanashi
  • Herbert Hacker

Organizations

  • Duke University

Tags

Communities of Interest

  • Biomedical
  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Amino Acids
  • Aromatic Amino Acids
  • Aspartic Acid
  • Chemical Reaction Properties
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Emission Spectra
  • Energy Transfer
  • Eye Diseases
  • Kinetics
  • Light Sources
  • Line Spectra
  • Oxidation
  • Rodents
  • Spin-Orbit Interaction
  • Two Dimensional

Fields of Study

  • Physics

Readers

  • Molecular and Cellular Biochemistry
  • Nuclear and Radiation Engineering.
  • Optical Physics and Photonics.

Technology Areas

  • Microelectronics