An Examination of the Feasibility of Administering Prophylactic Pyridostigmine by the Percutaneous Route.

Abstract

The feasibility of administering pyridostigmine by the percutaneous route was examined by the use of guinea pigs in vivo and their skin in vitro. Pyridostigmine has a possible use as a prophylactic against poisoning by organophosphorus esters. The compound enters the animal to inhibit blood cholinesterase, producing effects observable in 30 minutes. Evidence of the storage of pyridostigmine in skin was found. The compound when crossing skin in vitro takes 1,000 minutes to reach an equilibrium rate. A permeability constant of .000002 cm/min was estimated. The main problem remaining is the practical one of making a dosage form suitable for presenting the pyridostigmine at constant concentration to the skin for a long period. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1981
Accession Number
ADA099558

Entities

People

  • Hugh D. Crone
  • Michael P. Bladen

Organizations

  • Defence Science and Technology Group

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Alcohols
  • Animals
  • Australia
  • Blood
  • Chemical Synthesis
  • Chemistry
  • Dosage Forms
  • Engineering
  • Epidermis
  • Health Services
  • Materials
  • Materials Testing
  • Organic Chemistry
  • Organic Compounds
  • Rodents
  • Veins

Readers

  • Mathematics or Statistics
  • Toxicology/Environmental Toxicology