Epidemic Typhus Infection in Cynomolgus Monkeys (Macaca fascicularis)

Abstract

A nonhuman primate model of clinical Rickettsia prowasekii infection ws developed in cynomolgus monkeys (Macaca fascicularis). Monkeys infected intravenously with 10 (expn 7) plaque-forming unit developed clinical signs of illness and pathological changes characteristic of epidemic typhus infection in humans. Increases in total leukocyte counts, serum alkaline phosphatase, blood urea nitrogen, and serum glutamic pyruvate transaminase values were observed. Microscopic examination revealed typical typhus nodules in the brains of two monkeys that died. These data indicated that the cynomolgus monkey is a suitable model for study of the pathogenesis of epidemic typhus infection and may prove valuable in the evaluation of candidate R. prowazekii vaccines.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1980
Accession Number
ADA100070

Entities

People

  • Carl E. Pedersen Jr.
  • Janet C. Gonder
  • Richard H. Kenyon

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Blood
  • Brain
  • Cardiovascular System
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Electrocardiography
  • Experimental Design
  • Health Services
  • Infection
  • Laboratory Animals
  • Macaca Fascicularis
  • Monkeys
  • Rodents
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Immunology
  • Infectious Disease/Epidemiology
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology