Treatment of Klebsiella pneumoniae Respiratory Tract Infection of Squirrel Monkeys with Aerosol Administration of Kanamycin

Abstract

The therapeutic efficacy of IM-administered kanamycin was compared with the efficacy of aerosol-administered kanamycin in Klebsiella pneumoniae-infected squirrel monkeys. Differences in mortality or morbidity were not seen with equivalent dosages of antibiotic ranging from 15 to 6.9 mg/kg of body weight/day. Seemingly, the IM route of kanamycin administration was as effective as the aerosol route for therapy.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1980
Accession Number
ADA100090

Entities

People

  • Frank R. Frola
  • Richard F. Berendt
  • Robert D. Magruder

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Animals
  • Anti-Bacterial Agents
  • Body Weight
  • Clearances
  • Digestive System Processes
  • Infection
  • Materials
  • Monkeys
  • Morbidity
  • Organic Materials
  • Pneumonia
  • Respiratory Tract Diseases
  • Rodents
  • Squirrel Monkeys
  • Survival
  • Wound Infections

Readers

  • Microbial Pathology
  • Toxicology/Environmental Toxicology