The Role of Adrenergic Receptors in Norepinephrine Stimulated VO2 in Muscle,
Abstract
The purpose of this study was to characterize the norepinephrine (NE) calorigenic response of an isolated perfused rat muscle preparation into alpha and/or beta adrenergic components. The alpha agonist, phenylephrine, was as effective as NE in eliciting an increase in oxygen consumption by the muscle. Isoproterenol had no effect on the VO2 of the preparation. Phentolamine (.40 nM/g.min) an alpha blocker completely blocked the NE stimulated VO2. Propranol (.40 nM/g.min) in a sufficient dose, was also found to block the NE induced VO2 but this drug was found to be less potent. It was concluded that the NE induced calorigenic response of muscle cannot be classified either strictly as an alpha or beta response, but unlike brown adipose tissue, the alpha response seems to predominate in skeletal muscle. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1977
- Accession Number
- ADA100384
Entities
People
- Barbara Grubb
- G. E. Folk Jr.