The Teratogenic Effects of the Fuel JP-10 on the ICR Mice.

Abstract

JP-10 is a synthesized fuel for Cruise Missiles. It is the exoisomer of 4, 7-methano-1H-indene, octahydro 12a alpha, 4 alpha, 7 alpha, 7a alpha, (CA 2825-83-4). Pregnant ICR mice were given oral doses of 0.2, 0.4, 0.6 and 0.8 ml/kg on days 6 through 9 of gestation. No significant differences were found between controls and experimental groups in mean implants/female, mean viable fetuses/litter, mean resorptions/litter, frequency of resorptions, frequency of soft tissue anomolies and frequency of skeletal anomalies. Mean fetal weight was significantly heavier in the 0.2 and 0.4 ml/kg groups. This effect is difficult to explain when the 0.6 and 0.8 ml/kg groups showed no increase in fetal weight. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Mar 31, 1981
Accession Number
ADA101062

Entities

People

  • Robert D. Lyng

Organizations

  • Purdue University

Tags

Communities of Interest

  • Biomedical
  • Weapons Technologies

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Biomedical Research
  • Body Weight
  • Cruise Missiles
  • Frequency
  • Oils
  • Plant Oils
  • Scientific Research
  • Security
  • Soft Tissues
  • Tissues
  • Toxic Hazards

Readers

  • Analytical Mechanics
  • Toxicology/Environmental Toxicology