Metabolism of Hydrazine
Abstract
In rats exposed to atmospheric hydrazine, the log of blood hydrazine concentration was found to bear a more or less linear relation to atmospheric hydrazine levels. At 20-25 mg hydrazine/cu M, blood concentrations approached 100 nmole/ml, and were about 2 nmole/ml at atmospheric concentrations of about 3 mg/cu M. During exposure, blood concentrations tended to rise rather quickly in the first hour, then oscillated slowly around a generally constant level throughout six hours of exposure. Blood concentration of hydrazine following a single 1 nmole/kg dose decreased with a first phase halftime of about 45 minutes followed by a slower decrease with halftime of 27 hours. Less than one percent of such doses was excreted in bile. In vitro reaction of 5 m molar hydrazine in whole blood proceeded at a rate of about .016 micromole/m1/minute or about 10% in 30 minutes. With higher concentrations turnover becomes more rapid and can exceed the hemoglobin subunit equivalence by many fold. Extensive efforts to locate 15N/labelled urinary metabolities that would account for remaining uninventoried hydrazine have not yet succeeded.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1981
- Accession Number
- ADA101849
Entities
People
- B. M. Krivak
- D. J. Broderick
- D. J. Reed
- F. N. Dost
Organizations
- Oregon State University