Subeschar Antibiotic Infusion in the Treatment of Burn Wound Infection

Abstract

In a reproducible infected rat burn model, subeschar infusion of antibiotics failed to protect the animals from death via burn wound invasion excepting those animals receiving carbenicillin. Subcutaneous injection of maximal doses of carbenicillin at a distance from the burn wound protected these animals equally well. Some advantage was defined for the subeschar route of administration with suboptimal doses of carbenicillin. More important is the fact that prospective selection of an effective antibiotic could not be made on the basis of in vitro antibiotic sensitivity tests.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1980
Accession Number
ADA102821

Entities

People

  • Arthur D. Mason Jr.
  • Basil A. Pruitt Jr.
  • William F. McManus

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Abdomen
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Experimental Design
  • Infection
  • Infection Control
  • Infusions
  • Pseudomonas Infections
  • Sensitivity
  • Sepsis
  • Wound Infections
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Immunology
  • Infectious Disease/Epidemiology
  • Trauma or Military Medicine