Blood Cholinesterase as a Function of Physostigmine.

Abstract

The purpose of this research was to document, by the pH method, changes in blood cholinesterase after carbamate poisoning. Five doses of physostigmine and a placebo were injected into rhesus monkeys, and blood samples were taken periodically for 48 hours. Cholinesterase inhibition and behavioral symptoms were most severe during the first 4 hours post injection, and recovery was essentially complete by 8 hours. The results will be used to determine dose and temporal parameters in future studies with physostigmine. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1981
Accession Number
ADA102982

Entities

People

  • Dennis W. Blick
  • Grant D. Callin
  • Jackie Lanum
  • Michael E. Campbell
  • Thomas G. Wheeler

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aerospace Medicine
  • Air Force
  • Air Force Facilities
  • Animals
  • Blood
  • Blood Cells
  • Cells
  • Cells (Biology)
  • Enzyme Inhibitors
  • Government Procurement
  • Governments
  • Inhibition
  • Laboratory Animals
  • Recovery
  • Rhesus Monkeys
  • Security
  • Visual Perception

Fields of Study

  • Medicine

Readers

  • Neurotoxicology
  • Toxicology/Environmental Toxicology