Pulmonary Extravascular Fluid Dynamics in Oxygen Toxicity.
Abstract
The patho physiology of early pulmonary oxygen toxicity centers around injury to the Type 2 pneumocyte with a progressive disruption of surfactant structure, and a concomitant increase in intracellular and interstitial water content. We reasoned that the measurement of V sub tiss and D sub LCO during the onset of early pulmonary O2 toxicity would provide a more insightful, yet noninvasive, indicator of the underlying pathophysiology than a decrement in V sub C, since this would be caused by acute airway irritation, as by a reduction in pulmonary compliance, our studies were originally designed to determine the contribution of an early accumulation of lung water to the observed decrement in V sub C. Because of previous authoritative reports of a dose/response relationship between hyperbaric oxygen exposure and diminution in vital capacity, we were surprised to find no such relationship in our studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1980
- Accession Number
- ADA103816
Entities
People
- Enrico M. Camporesi
- John N. Miller
- Melissa Mcleod
- Robin Coggin
Organizations
- Duke University Hospital