Unique Effects of Infectious or Inflammatory Stress on Fat Metabolism in Rats.
Abstract
Infectious or inflammatory stress in the rat causes very typical functional and metabolic alterations. Among the most typical are elevation in body temperature, plasma copper, insulin, and glucagon and depression in the concentration of plasma ketones, free fatty acids and zinc. These changes occur only with infectious or inflammatory stress and not with noninflammatory stresses such as femoral fracture, screen restraint or exercise. It appears that the depression in plasma ketone bodies during infection or inflammation is closely related to the rise in plasma insulin. During infection imposed on experimentally induced diabetes, inhibition of plasma ketones is no apparent. In a similar fashion, infection in hypophysectomized rats causes no elevation in plasma insulin and no depression in plasma ketones. Discussion concerning the implications of these observations in the rat and primate is included. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 07, 1981
- Accession Number
- ADA104053
Entities
People
- Daniel J. Crawford
- Harold A. Neufeld
- Judith G. Pace
- Mitchell V. Kaminski
- Philip Z. Sobocinski
Organizations
- United States Army Medical Research Institute of Infectious Diseases