Benzodiazepine Hypnotics Increase Heart Rate During Sleep.

Abstract

Intravenous administration of benzodiazepines as preoperative sedatives produces cardiovascular changes including a short-lived elevation in heart rate (HR). Bedtime oral administration of triazolam (0.5 mg) and flurazepam (30 mg) was found to cause a HR increase of similar magnitude which was present during the first 4 hours of sleep. This peripheral effect was unexpected in view of the CNS sleep-promoting properties of benzodiazepine hypnotics. (Author)

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1981
Accession Number
ADA104063

Entities

People

  • Alain Muzet
  • Cheryl L. Spinweber
  • Laverne C. Johnson

Organizations

  • Naval Health Research Center

Tags

DTIC Thesaurus Topics

  • Amnesia
  • Anticonvulsants
  • Biomedical Research
  • Body Weight
  • Cardiovascular Physiological Phenomena
  • Central Nervous System
  • Classification
  • Computers
  • Elevation
  • Eye Movements
  • Heart Rate
  • Hypnotics And Sedatives
  • Measurement
  • Nervous System
  • Psychophysiology
  • Security
  • Smooth Muscle

Fields of Study

  • Medicine
  • Psychology

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Molecular Photonics/Laser Physics
  • Trauma Surgery or Emergency Medicine.