Exercise-Induced Changes in Metabolic Resposes to Infection in Trained Rats.
Abstract
Previous studies have demonstrated that swimming performance was reduced during bacterial infection. Studies were performed to determine whether endurance training alters performance related energy metabolism during Streptococcus pneumoniae infection in trained and untrained rats. Trained rats swam a 5-day/week for 4 weeks. Swim periods were increased daily be 10-min increments from an initial 10 min to 2 h in the second week, and continued for the 2 remaining weeks. Rats were inoculated with 100 live or heat-killed organisms/100 g BW and then fasted. Rats were studied immediately following a swim to exhaustion at 72 h postinoculation and onset of fast. Results indicate that training did not alter disease-related mortality or alleviate the infection-induced decrement in performance. Metabolically, training only blunted the effects of acute exercise, but did not change the infection-induced alteration. Trained rats were less susceptible to the exercise stress, while their performance capacity was more sensitive to the debilitating effects of the infection than untrained rats. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 20, 1981
- Accession Number
- ADA104114
Entities
People
- D. J. Crawford
- G. Friman
- H. A. Neufeld
Organizations
- United States Army Medical Research Institute of Infectious Diseases