Topical Hazard Evaluation Proagram of Candidate Insect Repellents, US Department of Agriculture Proprietary Chemicals.
Abstract
Preliminary hazard evaluations of the above candidate insect repellent chemicals were performed by means of laboratory animal studies using rats, rabbits, and guinea pigs. Chemicals AI3-37351a, 37352a, and 37564 were noninjurious to the eyes of rabbits. Chemical AI3-37563 caused mild injury to the cornea of rabbits and chemicals AI3-37347a, 37353a, 37560, 37561, and 37562 caused mild injury to the cornea and, in addition, some injury to the conjunctiva. All of the chemicals did not cause skin irritation with the exception of AI3-37353a which caused mild skin irritation. All chemicals were relatively nontoxic by ingestion and did not cause photoirritation or prove to be skin sensitizers. Chemicals AI3-37347a, 37352a, 37353a, 37563, and 37564 demonstrated some skin irritation from ethanol solutions during photoirritation studies. It was recommended that all chemicals be approved for further testing as candidate insect repellents. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 17, 1981
- Accession Number
- ADA104452
Entities
People
- John G. Harvey Jr.
- Michael J. Topper
Organizations
- United States Army Medical Command