Schistosome Materials for Vaccine Development.
Abstract
Large quantities of parasite materials (S. mansoni) were supplied to investigators at the National Naval Medical Research Institute in Bethesda, Maryland for immunoparasitological research. Research on host-parasite relationships designed (1) to weight the balance in favor of the schistosome and so increase the production of available material, and (2) to clarify the invasive mechanisms resulted in the following findings. There were differences in cercarial production in intra-specific Schistosoma mansoni-Biomphalaria glabrata strain models. In the model in use, variability was encountered in cercarial output, miracidial infectivity, and snail death rates. Causes of some of this variability were identified. The limits of variability under our conditions were specified. An optimal maintenance system for this schistosome-snail strain model was developed. Rotifer inhibition of cercarial output and motility was discovered. A jet spray wash control procedure for rotifers was designed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1981
- Accession Number
- ADA104756
Entities
People
- F. Lewis
- M. Stirewalt