Evaluation of Short-Term Bioassays to Predict Functional Impairment. Selected Short-Term Hepatic Toxicity tests.
Abstract
The MITRE Corporation has been requested by the U.S. Army Medical Bioengineering Research and Development Laboratory to identify and evaluate short-term bioassays which have demonstrated ability to assess and predict impairment of the hepatic system resulting from short-term exposure to chemicals. This document reviews the literature on test procedures for determining toxic effects on the liver. The procedures are discussed in sections on morphology, function and biochemistry. Criteria for evaluating the procedures are given. A three-tiered testing system is recommended for a chemical hepatotoxicity screening program. This report is accompanied by a directory entitled Development of Hepatic Bioassays in Laboratory Animals: Directory of Institutions/Individuals. The Directory catalogues the individuals and organizations currently engaged in hepatic bioassay utilization or development, and provides information concerning specific measurements performed, test systems employed, compounds tested, requirements for anesthesia, and the terminal nature of the test. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1980
- Accession Number
- ADA104762
Entities
People
- Awadh Singh
- Lydia Thomas
- Ralph Wands
- Richard D Thomas
Organizations
- MITRE Corporation