24-Hour Mean Plasma Hormone Levels in Men with Coronary Heart Disease.
Abstract
Plasma concentrations of 14 hormones or hormone metabolites and urinary excretion of 15 hormones or hormone metabolites were studied in four rigorously selected groups: 13 men who had recovered well from prior myocardial infarction (at least 6 months earlier), 35 clinically normal men, 25 men with severe coronary artery disease diagnosed by coronary arteriograms but no history or signs of myocardial infarction, and 44 men with normal coronary arteriograms. Aside from a minor finding that a subset of the post-infarction patients (3 out of 12) showed subnormal plasma T3 levels (? the non-specific low-T3 syndrome), there were four major findings: post-infarction patients had significantly higher 24-hour mean plasma concentrations of estrone (80 vs 49 pg/ml, P <0.0001), dehydroisoandrosterone (444 vs 298 ng/dl, P <0.025), and dehydroisoandrosterone sulfate (112 vs 72 micro g/dl, P = 0.05) than clinically normal men, while men with positive coronary arteriograms but no infarction had the same levels as men with negative arteriograms; men with positive arteriograms but no infarction had significantly lower urinary excretion of androsterone glucuronide (2.6 vs 3.2 mg/g creatinine, P <0.05) than men with negative arteriograms, while post-infarction patients excreted normal amounts of this steroid. In the case of all three differing plasma steroids, nearly all the post-infarction patients had values at or below the upper 95% confidence limit of the normal range; the significant elevation of the post-infarction patients' mean value was due in each case to clustering of the patients' values in the upper half of the normal range.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1981
- Accession Number
- ADA105050
Entities
People
- Barnett Zumoff
- David K. Fukushima
- James J Hickman
- Raymond G. Tropler
- Robert S. Rosenfeld