Histocompatibility Typing for the Prediction of Susceptibility to Infectious Disease.
Abstract
The objective of this contract is to determine if susceptibility to certain infectious agents or morbidity associated with infection can be predicted based on knowledge of HLA type. The contract was established to design and conduct studies that will indicate if one can predict an individual's ability to mount an immune response to an active infection causing disease or to a practical vaccine based on a knowledge of genes within the HLA region. The population chosen for the index study comprises individuals who as infants suffered respiratory syncytial virus (RSV) infection, where a small number developed bronchiolitis requiring hospitalization while most recovered with no severe side effects. Association and/or linkage between HLA, virus infection (seroconversion) and morbidity (bronchiolitis) as well as a number of other factors has been evaluated within the random sample population and within families using standard statistical methods.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1981
- Accession Number
- ADA106660
Entities
People
- Armead H. Johnson
Organizations
- Georgetown University