Heat-Induced Changes in Perfused Rat Liver,

Abstract

In order to determine the time periods at which heat-induced structural changes occurred, isolated rat livers were perfused for different time intervals at 41 - 43 C with oxygenated Krebs-Ringer bicarbonate containing .14% glucose. Structural changes occurred after 60 minutes at 41 C, 30-45 minutes at 42 C and 15 minutes at 43 C. Under these perfusion conditions, structural changes were detected before bile production or enzyme leakage reflected changes. The data suggest a continuum of events depending on the time and temperature of exposure, leading to the same end point: loss of endothelium, vacuolization, loss of microvilli, and formation of flocculent densities in mitochondria. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Sep 28, 1981
Accession Number
ADA106725

Entities

People

  • Dominique N. Wagner
  • Michael J. Murphy
  • P. Chisholm
  • R. Hubbard
  • W. D. Bowers Jr.

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Acid-Base Equilibrium
  • Amino Acids
  • Cells
  • Cellular Structures
  • Electron Microscopes
  • Electron Microscopy
  • Electrons
  • Endothelial Cells
  • Endothelium
  • Experimental Data
  • Flow Rate
  • Microscopy
  • Military Research
  • Mitochondria
  • Perfusion
  • Production
  • Time Intervals

Readers

  • Mathematics or Statistics
  • Toxicology/Environmental Toxicology