Kinetics of Neutrophil-Releasing Activity of Post-Leukapheresis Plasma.

Abstract

Humoral factors are elaborated by animal and human granulocyte donors during filtration leukapheresis. Plasma obtained from leukapheresed rats (PPP) may be used to increase granulocyte yields in donors when given prior to leukapheresis. This effect is dose and time related. The titer of neutrophil releasing activity is related to the duration of pheresis. There is positive correlation between the donor pre- and postgranulocyte count and the titer of neutrophil releasing activity of the PPP. This activity in PPP is stable for up to three weeks at 4 C. The maximum granulocyte increment observed following injection of PPP occurs at three hours after injection. Intraperitoneal injection of PPP is ineffective.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1981
Accession Number
ADA107541

Entities

People

  • Albert J. Roy

Tags

DTIC Thesaurus Topics

  • Arteries
  • Biomedical Research
  • Blood
  • Blood Cells
  • Blood Proteins
  • Cell Count
  • Cells
  • Filtration
  • Fungi
  • Granulocytes
  • Health Services
  • Hematologic Diseases
  • Leukocytes
  • Materials
  • Rodents
  • Therapy
  • Veins

Fields of Study

  • Biology

Readers

  • Immunology