Mammalian Toxicological Evaluation of DIMP and DCPD (Phase 3 - IMPA)
Abstract
IMPA (Isopropyl Methylphosphonic Acid) had oral LD50's of 7650 and 6070 mg/kg in male and female rats. respectively, and of 5620 and 6550 mg/kg in male and female mice. It was not irritant to rabbit eyes. It was mildly irritant to rabbit skin but produced no systemic toxicity at a dose of 2 mg/kg. IMPA did not induce dermal sensitization in guinea pigs. No evidence of toxicity followed administration of IMPA in the drinking water at levels up to 3000 ppm to rats for 90 days. IMPA was not mutagenic to five strains of Salmonella indicator organisms in the Ames assay both with and without rat liver activation.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1981
- Accession Number
- ADA107574
Entities
People
- Francis J. Mecler