The Effects of Acidification of Drinking Water on Selected Biological Phenomena in Mice.
Abstract
This study was done to determine if the consumption of water acidified with either hydrochloric or sulfuric acid to a pH of 2.0 or 2.5 produced significant effects in normal and immunosuppressed male random-bred mice. The phenomena evaluated included the following: water pH stability; weight; food and water consumption; state of hydration; stomach and small intestinal pH; stomach acid content; small intestine disaccharidase activity; liver microsomal enzyme activity; histopathologic tissue examination; and bacterial flora of the terminal ileum. Throughout the weekly test periods the pH of the drinking water remained stable. Weight gain was significantly reduced (p<0.05) in the non-immunosuppressed mice receiving drinking water acdified to a pH of 2.0 with both acids. Weight gain of the immunosuppressed mice was also significantly reduced (p<0.05). Water consumption was significantly reduced (p<0.05) in male mice consuming pH 2.0 acidified water with both acids.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1979
- Accession Number
- ADA107969
Entities
People
- James Edward Hall
Organizations
- Air Force Institute of Technology