Assessment of Antiradiation Drug Effectiveness to Fission Neutron Irradiation.
Abstract
This report deals with the assays of various compounds for their toxicity of anti-radiation efficacy following exposure to either Co-60 or fission neutron irradiation. The compounds reported herein include WR 347, WR 2721, WR 3689, WR 44923, WR 109342, WR 151327, WR 16843, and WR 176542. The end-points measured in the radiation studies were LD50(6) and LD50(30). The compounds and their dose modification factors (DMF) for the neutron LD50(6) following i.p. administration, were, in descending order of effectiveness: WR 151327 (1.42), WR 347 (1.37), WR 3689 (1.34) WR 44923 (1.34), WR 2721 (1.26), WR 168643 (1.24), and WR 176542 (1.23). The corresponding LD50(30)'s for fission neutron irradiation following i.p. administration, were: WR 168643 (1.67), WR 3689 (1.52), WR 151327 (1.45), WR 44923 (1.39), WR 347 (1.22), WR 2721 (1.21), and WR 176542 (1.18). For low LET Co-60 gamma irradiation the LD50(6) and LD50(30) were determined for WR 347 following i.p. administration. The DMF's obtained were: LD50(6) (1.4), LD50(30) (1.5). (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1981
- Accession Number
- ADA108295
Entities
People
- Curtis P. Sigdestad
Organizations
- University of Louisville