Molecular Interactions of High Energy Fuels and Jet Fuels with Oncogenic Viruses and Endogenous Viruses.
Abstract
The objectives of this research are to develop rapid in-vitro assays to evaluate the carcinogenic potential of chemicals used by the U.S. Air Force. Snyder-Theilen Feline Sarcoma Virus (ST FeSV), quantitatively transforms human skin fibroblasts following second order kinetics. These studies were performed in order to determine whether chemicals altered ST FeSV transformation in a predictable manner and to correlate the alteration with the carcinogenic or non-carcinogenic activity of the text chemical. The results, to date, show diverse carcinogens classed as: aromatic amines, polycyclic hydrocarbons, Aminofluorenes, hydrazines, asbestos and mycotoxins inhibited virus transformation when virus infected cells (2 hours post-infection) were exposed to test chemical, while non-carcinogenic chemicals had no significant effect on transformation. Triton X-100, acetone, petroleum and shale oil derived JP5; RJ5 and diesel fuel, marine, demonstrated non-carcinogenic activity while formaline demonstrated carcinogenic activity. Experiments designed to show the specificity of the antagonistic effect of known carcinogens are reported. Disulfuram inhibits biotransformation of 1,2 symmetrical dimethyl hydrazine (SDMH) metabolites, azomethane to azoxymethane (ultimate carcinogen) thereby preventing carcinogenic effect of the proximate carcinogen SDMH. Detailed methodology required to ascertain effect of chemicals on ST FeSV pro-virus integration and synthesis are presented.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1981
- Accession Number
- ADA108377
Entities
People
- James R. Blakeslee Jr
Organizations
- Ohio State University