Topical Hazard Evaluation Program of Candidate Insect Repellents, US Department of Agriculture Proprietary Chemicals, October 1978 - September 1981.
Abstract
Preliminary hazard evaluations of the above candidate insect repellent chemicals were performed by means of laboratory animal studies using rats, rabbits, and guinea pigs. Chemicals AI3-37565, 37567, 37569, 37570, 37571, 37572, 37574 and 38010 did not cause any skin irritation. Chemical AI3-37566 and 37578 caused mild primary skin irritation. Chemical AI3-37574 was noninjurious to the eyes of rabbits. Chemicals AI3-37565 and 37572 caused mild injury to the cornea and chemicals AI3-37566, 37567, 37569, 37570, 37571, 37578, and 38010 caused mild injury to the cornea and, in addition, some injury to the conjunctiva. All chemicals were relatively nontoxic by ingestion and did not cause photoirritation or prove to be skin sensitizers. Chemicals AI3-37570 and 37574 demonstrated some skin irriration from ethanol solutions during photoirritation studies. It was recommended that all chemicals be approved for further testing as candidate insect repellents. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 09, 1981
- Accession Number
- ADA108668
Entities
People
- John G. Harvey Jr.
- Michael J. Topper
Organizations
- United States Army Medical Command