Comparison of Skin Sensitization Methods: Landsteiner, Maguire and Guinea Pig Maximization

Abstract

Comparison was made of three skin sensitization procedures: Landsteiner, Maguire, and Guinea Pig Maximization. Dinitrochlorobenzene, formaldehyde and Carbowax 4000 were selected as strong, weak to moderate, and non-sensitizers, respectively. The Maguire Test was most consistent in detecting the effects of these materials in the predicted order. Micropathologic examination of tissue at application sites did not increase the accruacy or precision of the tests.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1981
Accession Number
ADA110633

Entities

People

  • Andrew O. Hall
  • Edmond H. Vernot
  • J. R. Horton
  • James Douglas MacEwen

Organizations

  • University of California

Tags

Communities of Interest

  • Biomedical

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  • Abstracts
  • Accuracy
  • Air Force
  • Animals
  • Bandages
  • Biomedical Research
  • California
  • Contracts
  • Formaldehyde
  • Government Procurement
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  • Test And Evaluation
  • Test Methods
  • Toxic Hazards
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Readers

  • Materials Science and Engineering.
  • Regression Analysis.
  • Toxicology/Environmental Toxicology