Chemical Carcinogen-Induced Changes in tRNA Metabolism in Human Cells.
Abstract
Changes in nucleic acid catabolism were found in human cells transformed by an activated derivative of 1,2-dimethylhydrazine, with increased generation of 7-methylguanine being the major alteration. 7-Methylguanine was shown to inhibit the enzyme tRNA: guanine transglycosylase. This enzyme exchanges queuine (Q-base) for guanine in the first position of the anticodon of four different tRNA's, and tRNA's from transformed cells are Q-deficient. 7-Methylguanine was also found to induce Q-hypomodification of tRNA in normal cells. It is felt that the changes discovered in nucleic acid catabolism and modification may be involved in the expression of carcinogenesis. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1981
- Accession Number
- ADA112358
Entities
People
- Ronald W. Trewyn
Organizations
- Ohio State University