A Large Animal Model of Burn Hypermetabolism
Abstract
Further research on postburn hypermetabolism is limited by the constraints of patient studies and the reduced responses of small animal models. To test the validity of a large animal model, oxygen uptake (V sub O2), urinary excretion of epinephrine (E), norepinephrine (NE), and dopamine (DA), and rectal temperature were monitored in conscious 20- to 40-kg goats for 3 weeks following a 25% total body surface burn. While V sub O2 and catecholamine output remained at control levels in sham burned animals, V sub O2 rose from 5.57 + or - 0.23 ro 6.66 + or - 0.31 ml/min-kg (mean + or - SEM) in one group of seven injured animals 8 to 10 days postinjury. Excretion of E and NE in four injured goats was three to four times that in four sham-burned animals 7, 14, and 21 days postburn. Dopamine output was comparable in the two groups. There was no measurable change in rectal temperature after injury. Injured animals maintained body weight and did not become bacteremic. The hypermetabolic and neuroendocrine responses of the injured goat make this large animal an appropriate model for further research.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1981
- Accession Number
- ADA112684
Entities
People
- Arthur D. Mason Jr.
- Avery A. Johnson
- Douglas W. Wilmore
- Howard Aulick
- Wallace B. Baze
Organizations
- United States Army Institute of Surgical Research