Super Hydrides.
Abstract
The unusual reactivity of lithium triethylborohydride (Super Hydride) encouraged us to examine the selective reduction properties of a number of new reducing agents. Lithium trialkylborohydrides (LiR3BH) reduce most of the organic functional groups rapidly. On the other hand, lithium borohydride (LiBH4) is a mild reducing agent. In order to develop new reagents which can be used for specific reductions, the alkali metal dialkylborohydrides (MR2BH2) and alkylborohydrides (MRBH3) were prepared successfully. Although the full potentialities of these reagents are yet to be explored, preliminary studies have shown very encouraging results. We have developed new improved methods for the reduction of esters, nitriles, and amides with the convenient and readily available reagent, borane-dimethyle sulfide (BH3.SMe2, BMS). These developments have simplified the reduction of such functional groups. Lithium borohydride, a relatively expensive, but useful, reducing agent, has been prepared from sodium borohydride. This method is generally applicable for the preparation of various borohydrides.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 18, 1982
- Accession Number
- ADA113229
Entities
People
- Herbert C. Brown
Organizations
- Purdue University