Drug Exposed to Extreme Cold: The Military Perspective

Abstract

A list of drugs identified as being damaged by freezing (68 of 153 items) was excerpted from the 668 Authorized Medical Allowance List (AMAL). Freeze/thaw stability data was obtained from both the literature and innovator drug companies for over one half (45 of 68) of these items. A summary of recommendations for use in cold operations of these 68 items was prepared. Recommendations ranged from conservative (in those cases where no information was available) to liberal (where drug companies were concerned with efficacy). Recommendations also included the substitution of some items on the list with drugs of similar action but not needing freeze protection.

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Document Details

Document Type
Technical Report
Publication Date
Nov 11, 1981
Accession Number
ADA113544

Entities

People

  • Kenneth R. Bondi
  • Michael L. Shea
  • Robert A. Margulies
  • Robert M. Debell

Organizations

  • Naval Submarine Medical Research Laboratory

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cold Weather Operations
  • Dermatologic Agents
  • Dosage Forms
  • Health Services
  • Hospitals
  • Literature
  • Materials
  • Military Research
  • Packaging
  • Pharmacies
  • Potassium Chloride
  • Sodium Compounds
  • Test Methods
  • Vaccines

Fields of Study

  • Psychology

Readers

  • Defense Technology Research and Development.
  • Systems Analysis and Design
  • Thermal Physics or Thermal Science.