Dermal Sensitization Potential of Candidate Insect Repellents: LAIR Formulation (CHF1) N-(n-octyl) glutarimide (CHR2) N-(n-hexyl) glutarimide (CHR3) (E) 1,2,3,4-tetrahydro-6-methyl-1-(2-methyl-1-oxo-2-butenyl)quinoline (CHR5) 1,2,3,4-tetrahydro-6-methyl-1-(3-methyl-1-oxo-2-butenyl) quinoline (CHR6).

Abstract

Arthropods represent a potential disease threat to U.S. Military Forces; consequently, a program to develop improved insect repellents was developed. The dermal sensitization potential of candidate insect repellents was determined using guinea pigs. Test substances CHF1, CHR2, and CHR3 were clearly non-sensitizing. CHR5 and CHR6 were irritating, possibly sensitizing, and should be retested. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1982
Accession Number
ADA113586

Entities

People

  • John T. Fruin
  • Kenneth Black
  • Martha A. Hanes
  • Virginia L. Gildengorin

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alcohols
  • Animals
  • Biomedical Research
  • Boiling Point
  • Chemical Compounds
  • Insect Repellents
  • Laboratory Animals
  • Materials
  • Medical Personnel
  • Molecular Weight
  • Propylene Glycol
  • Rodents
  • Toxicity
  • Toxicology
  • United States
  • United States Government

Fields of Study

  • Chemistry

Readers

  • Toxicology/Environmental Toxicology