Glucose-Dependent Insulin Inhibition of Ketone Body Formation from Long-Chain Fatty Acids in the Perfused Livers of Fasted Rats

Abstract

The data presented in this report show a direct effect of insulin on impairment of ketone body production in perfused livers from fasted rats. The data also show that physiological levels of insulin alone or glucose alone are not sufficient to cause an impairment in ketogenesis. Only when insulin and glucose are both present at levels seen in infected rats is ketone body production impaired.

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Document Details

Document Type
Technical Report
Publication Date
Apr 13, 1982
Accession Number
ADA114703

Entities

People

  • David L. Bunner
  • Francis Beall
  • Harold A. Neufeld
  • Judith G. Pace

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Buildings And Structures
  • Chemical Compounds
  • Endocrinology
  • Fatty Acids
  • Inhibition
  • Ketones
  • Lipids
  • Oleic Acid
  • Perfusion
  • Production
  • Research Facilities

Fields of Study

  • Biology

Readers

  • Analytical Chemistry
  • Cardiovascular Physiology