Studies on the Antigenic Relationship among Phleboviruses

Abstract

The antigenic relationship of the 31 currently recognized phlebotomus fever group viruses was examined by plaque reduction neutralization test. Although some low-level cross-neutralization was observed, each of the viruses was easily differentiated by this method. Rift Valley fever virus was shown to be antigenically related to Candiru, Frijoles, Karimabad and Punta Toro viruses. Naples, Tehran and Toscana viruses were also shown to be closely related. Preliminary results of indirect fluorescent antibody tests indicate that this technique is broadly reacting and less specific than either the complement-fixation or neutralization test for identifying phlebotomus fever group viruses. A discussion follows on some of the difficulties encountered in attempting to classify phleboviruses.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1982
Accession Number
ADA115198

Entities

People

  • Clarence J. Peters
  • James M. Meegan
  • Robert B. Tesh

Organizations

  • Yale University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Antigens
  • Arboviruses
  • Biomedical And Dental Materials
  • Body Fluids
  • Bunyaviridae
  • Health
  • Immune Serums
  • Infectious Diseases
  • Neutralization
  • Phlebotomus Fever
  • Public Health
  • Rift Valley Fever
  • Rift Valleys
  • Rodents
  • Viruses
  • Zoonoses

Fields of Study

  • Biology

Readers

  • Systems Analysis and Design
  • Virology (or Medical Virology).