Oxygen-Carrying Resuscitation Solutions
Abstract
Two important functions of blood are represented by the ability of red cells to reversibly bind and transport oxygen to the tissues and the ability of plasma proteins to maintain oncotic pressure. Because blood is a limited and valuable resource and has a relatively short storage life, several investigators have been attracted for many years to the development and evaluation of oxygen-carrying resuscitation solutions which could fulfill the functions of blood when administered for fluid-replacement therapy. Significant progress in these studies has been achieved in recent years. Investigative efforts have been intensified in view of several reports demonstrating that oxygen-carrying resuscitation solutions, used in essentially complete replacement of blood, can maintain life. Adverse biological effects, observed in earlier studies, have been addressed by several investigators, with the objective of obtaining safe and effective products. These activities have led to substantial improvements in the quality and purity of experimental oxygen-carrying resuscitation solutions. A clearer understanding has been achieved concerning the capabilities and the limitations of the products currently available. This clearer picture has allowed delineation of those manipulations necessary to modify the present resuscitation solutions for systematic improvements. New and better products have been developed recently and are currently being evaluated in experimental animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1982
- Accession Number
- ADA115976
Entities
People
- Frank Devenuto
Organizations
- Letterman Army Hospital