Analysis of Orthochloronitrobenzene in Otto Fuel II by High Pressure Liquid Chromatography

Abstract

Orthochloronitrobenzene (OCNB) is a trace contaminant in Otto Fuel II (OFII), a nitrated ester used as a torpedo propellant by the U.S. Navy. In a published study, OCNB has been reported to produce multiple life tumors in male and female rats. The quantification of OCNB in OFII was performed by high pressure liquid chromatography. The OFII was found to contain 0.00165% OCNB and a distillate of OFII was found to contain 0.009% OCNB. It was estimated that over a 12 month inhalation exposure to 240 mg/cu m of OFII an animal would receive a total dose of 0.05 mg OCNB per kilogram of body weight. This is insignificant compared to the total dose required for the previously published results. OCNB is not considered to be a factor in the outcome of the current studies.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1982
Accession Number
ADA116305

Entities

People

  • A. K. Roychowdhury
  • Edmond H. Vernot
  • James Douglas MacEwen
  • R. L. Einhaus
  • R. L. Hilderbrand

Organizations

  • University of California

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  • Biomedical

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  • Air Force
  • Biomedical Research
  • Calibration
  • California
  • Chromatography
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  • Government Procurement
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  • High Pressure
  • Liquid Chromatography
  • Measurement
  • Otto Fuels
  • Standards
  • Technical Information Centers
  • Toxicology
  • Universities

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  • Gender and Food Studies
  • Petroleum Engineering
  • Toxicology/Environmental Toxicology