Respiratory Adaptation to Acute Metabolic Acidosis in Goats with Ablated Carotid Bodies,
Abstract
In awake goats before and after ablation of carotid bodies (CBx) we studied the effect of acute metabolic acidosis (AMA) produced by intravenous infusion of HC1 on resting pulmonary ventilation, on composition of arterial blood and CSF, and on ventilatory responsiveness to hyperoxic CO2 rebreathing. AMA caused decrease in PaCO2 (breathing air at rest) and shifted the position of CO2 response curves toward lower values of PCO2. These changes were similar before and after CBx, though the levels of PCO2 in arterial blood during air breathing, and in expired gas at a given level of ventilation during CO2 rebreathing were higher after CBx. We conclude that a respiratory adaptation to AMA does occur in goats deprived of peripheral chemoreceptors, and is probably mediated by the central chemoreceptors. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 03, 1982
- Accession Number
- ADA116657
Entities
People
- D. E. Leith
- J. C. Donovan
- R. A. Gabel
- R. A. Steinbrook
- S. Havaheri
Organizations
- United States Army Research Institute of Environmental Medicine