Ion-Selective Electrodes for Basic Drugs.

Abstract

This paper describes the preparation and evaluation of electrodes selective to methadone, cocaine, protriptyline, and methylamphetamine. These compounds were chosen because they are protonated amines in the physiologic pH range, and are representative of some important families of pharmaceuticals: methylamphetamine (MW = 150) a central nervous system stimulant; protriptyline (MW = 263) an anti-depressant; methadone (MW = 310) a narcotic analgesic; and cocaine (MW = 303) a local anaesthetic. Coated-wire ion-selective electrodes based on dinonylnaphthalene sulfonic acid (DNNS) are prepared for methadone, methylamphetamine, cocaine, and protriptyline in protonated form. In each set, nearly Nernstian responses are obtained. Selectivity is found to decrease in the order methadone, protriptyline, cocaine, and methylamphetamine; results which are consistent with systematic selectivity studies reported earlier for electrodes in this family.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1981
Accession Number
ADA116805

Entities

People

  • Henry Freiser
  • Larry Cunningham

Organizations

  • University of Arizona

Tags

Communities of Interest

  • Sensors

DTIC Thesaurus Topics

  • Buffers (Chemistry)
  • Calibration
  • Central Nervous System
  • Chemical Synthesis
  • Chemistry
  • Detection
  • Detectors
  • Drug Abuse
  • Electrodes
  • Ion Selective Electrodes
  • Ions
  • Materials
  • Materials Science
  • Measurement
  • Methadone
  • Military Research
  • Nervous System

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Electrochemical Surface Science
  • Polymer Science and Technology

Technology Areas

  • AI & ML
  • AI & ML - Neural Networks