Distamycin Analogs as Potential Antimalarials.

Abstract

New synthetic procedures have been developed which resulted in efficient syntheses of the permethyl analogues of distamycin, an antiviral antibiotic. Methods were also developed for selective acylations among amine, amidine, and guanidine functionalities. None of the compounds synthesized were effective against malaria. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1980
Accession Number
ADA116812

Entities

People

  • Henry Rapoport

Organizations

  • University of California, Berkeley

Tags

DTIC Thesaurus Topics

  • Absorption
  • Absorption Spectra
  • Acylation
  • Amines
  • Analogs
  • Antimalarials
  • Bibliographies
  • Biomedical Research
  • California
  • Carboxylic Acids
  • Chromophores
  • Contracts
  • Guanidines
  • Peptides
  • Students
  • Technical Information Centers
  • Universities

Fields of Study

  • Chemistry

Readers

  • Organic Chemistry
  • Parasitology and Pharmacology of Malaria.