Doxycycline Prophylaxis of Scrub Typhus.
Abstract
Recently, doxycycline was used in a large scrub typhus prophylaxis study in Taiwan. The drug was well tolerated and apparently effective, but interpretation of the results of this study is hampered by the low incidence of scrub typhus in the control subjects and the failure of some treated subjects to comply with the prophylactic regimen. We also have studied the efficiency of doxycycline as a prophylactic drug for scrub typhus. In our prospective, randomized, double-blind, placebo-controlled study, volunteers were given weekly 200 mg doses of doxycycline and deliberately infected. Additionally, we tested the efficacy of a single dose of doxycycline in the therapy of early scrub typhus. The results of these studies from the basis of this report.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 18, 1982
- Accession Number
- ADA117303
Entities
People
- Akira Shirai
- David L. Huxsoll
- G. Selvaraju
- J. Peter Saunders
- John C. Twartz
Organizations
- Institute for Medical Research