The Etiology and Pathogenesis of Viral Gastroenteritis.
Abstract
The purpose of this project is to identify, cultivate, and characterize etiologic agents of viral gastroenteritis of man and to study the pathogenesis of infection in order to provide information necessary to attain the ultimate goals of prevention and cure of this common syndrome. Progress achieved during the current year can be summarized as follows. Monoclonal antibody techniques have been utilized successfully to prepare purified antibodies against Norwalk virus with 5 positive clones now prepared. These monoclonal antibodies are being tested as probes to detect a potential group specific antigen common to the noncytopathic Norwalk-like virus group and to recognize these viruses in nature. In addition, studies are underway to try to cultivate Norwalk virus, using methods that proved successful for the in vitro cultivation of hepatitis A virus and rotavirus.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1982
- Accession Number
- ADA117709
Entities
People
- Neil R. Blacklow
Organizations
- University of Massachusetts Medical School