Effect of Chemical Mutagens on Herpes Virus-Induced Cellular Transformation and Testing for Mutagenesis in Mouse Cells.

Abstract

Assays which detect quantitative increases of morphological transformation in 3T3 cells were employed to detect transformation by seven temperature sensitive (ts) mutants of herpes simplex type 2 virus (HSV-2). It was determined that all seven mutants caused transformation at the non-permissive temperature. Mutant A8 (293) caused formation of the most foci and appeared to be a more sensitive indicator of transformation in comparative experiments (31 foci per million cells compared to four foci per million cells for ultraviolet-irradiated wild type virus). (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1982
Accession Number
ADA117727

Entities

People

  • F. Brent Johnson

Organizations

  • Brigham Young University

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Abstracts
  • Air Force
  • Carcinogens
  • Cell Physiological Processes
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Dimethylhydrazines
  • Environmental Protection
  • Hydrazines
  • Indicators
  • Infection
  • Nitroso Compounds
  • Plastic Explosives
  • Recovery
  • Urethanes
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Virology (or Medical Virology).