The Electrophysiologic Mechanisms of Halogenated Alkane Arrhythmogenesis.
Abstract
Bromochlorodifluoromethane (1211) has been shown to sensitize the myocardium to the arrhythmogenic effects of various adrenergic amines. The effects of certain physiologic and pharmacologic interventions were tested, including stretching of the tissue fiber, alpha adrenergic interations, cyclic adenosine monophosphate interactions and beta blockade of slow ion channel stimulation. Other studies indicate that 1211 has no apparent direct arrhythmogenic action on the dog heart, but acts only to sensitize the heart to adrenergic amines. Present studies indicate that 1211, like beta adrenergic amines, elevates cellular cyclic adenosine monophosphate levels which, through second messenger action, contributes to the alterations in cardiac membrane properties produced by these agents. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 28, 1982
- Accession Number
- ADA117754
Entities
People
- S. Mark Strauch
Organizations
- Ohio State University