A Neurobehavioral Study of Rats Using a Model Perfluorinated Acid, NDFDA.

Abstract

Fischer 344 rats were treated with 10,20, or 30 mg/kg of nonadecafluorodecanoic acid (NDFDA) on day 12 of gestation. Negative controls were given the vehicle (propylene glycol and water; 50:50) and positive controls were given a single ip injection of 500 mg/kg hydroxyurea (diluent, physiological saline). Developmental eruption, eye opening, and growth) and behavior, NDFDA was found to produce increased visuomotor development (visual placing). It is also caused decreased prenatal and postnatal weight gain, delayed cliff avoidance and surface righting, decreased open field rearing, aberrant swimming development and increased auditory startle. The observed effects indicate that NDFDA is a potential toxic neurochemical teratogen. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jul 13, 1982
Accession Number
ADA118560

Entities

People

  • Inez R. Bacon

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abdomen
  • Air Force
  • Animal Structures
  • Biomedical Research
  • Body Weight
  • District Of Columbia
  • Fire Extinguishers
  • Locomotion
  • Pregnancy
  • Propylene Glycol
  • Scientific Research
  • Security
  • Survival
  • Swimming
  • Teratogenic Compounds
  • Universities
  • Urea

Fields of Study

  • Biology

Readers

  • Toxicology/Environmental Toxicology