Pharmacological Studies on Clostridial Neurotoxins.

Abstract

Experiments have been done that compare the actions of botulinum toxin type A, tetanus toxin, diphtheria toxin and beta-bungarotoxin on the cholinergic neuromuscular junction. All four toxins bind to tissues without producing adverse effects; each of the toxins has its own unique class of receptors. After tissue binding has occurred, botulinum toxin, tetanus toxin and diphtheria toxin are internalized; this process is antagonized by chloroquine, ammonium chloride and methylamine hydrochloride. Beta-Bungarotoxin is not internalized and is not antagonized by the drugs just listed. Diphtheria toxin acts intracellularly to ADP-ribosylate elongation factor 2. The intracellular actions of botulinum toxin and tetanus toxin have not been determined.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1982
Accession Number
ADA118812

Entities

People

  • Lance L. Simpson

Organizations

  • Columbia University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amines
  • Anesthesia
  • Animals
  • Autonomic Nervous System
  • Bacterial Toxins
  • Cardiovascular Physiological Phenomena
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Cholinergic Nerves
  • Eukaryotes
  • Medical Personnel
  • Nervous System
  • Peripheral Nervous System
  • Rodents

Fields of Study

  • Biology

Readers

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