Comparative Biochemistry and Metabolism. Part 1. Carcinogenesis

Abstract

The inorganic reducing agent, hydrazine, is toxic and weakly carcinogenic. In earlier studies it was found that oral administration of a toxic dose of hydrazine to the rat resulted in methylation of liver DNA guanine moieties with an apparent dependency upon endogenous S-adenosylmethionine as the source of the methyl group. Further studies have been carried out to confirm the identity of these methylated bases in DNA as 7-methylguanine and 06- methylguanine, to determine the rates of their formation and the duration of their persistence in DNA, and to investigate possible mechanisms by which hydrazine might stimulate the methylation of liver DNA.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1982
Accession Number
ADA119124

Entities

People

  • Richard A. Becker
  • Ronald C. Shank
  • William S. Bosan

Organizations

  • University of California, Irvine

Tags

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Biochemistry
  • Biomedical Research
  • Body Weight
  • Chemical Synthesis
  • Chemistry
  • Chromatography
  • Cold Water
  • Hydroxides
  • Liquid Chromatography
  • Mass Spectrometry
  • Nucleic Acids
  • Nucleosides
  • Ribonucleic Acids
  • Risk Analysis
  • Spectra

Readers

  • Immunology
  • Molecular and genetic basis of cancer.
  • Polymer Science and Technology