Disposition and Metabolism of Investigational New Drugs.

Abstract

During the 39-month experimental period, studies were undertaken to determine absorption, excretion, metabolism and pharmacokinetics in rats, dogs, or rhesus monkeys following single oral doses of 14C-labeled antimalarial chemicals. Samples including blood, excreta, and selected other tissues/organs were collected at various time intervals following dosing and analyzed for 14C content. Selected tissues and excreta were extracted and subjected to thin-layer chromatography (TLC) to determine metabolic profiles.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1982
Accession Number
ADA119355

Entities

People

  • Thomas E. Shellenberger

Organizations

  • MRIGlobal

Tags

DTIC Thesaurus Topics

  • Absorption
  • Alcohols
  • Antimalarials
  • Biological Sciences
  • Biomedical Research
  • Chemistry
  • Contracts
  • Excretion
  • Laboratory Animals
  • Metabolism
  • Monkeys
  • Pharmacology
  • Propanols
  • Rhesus Monkeys
  • Technical Information Centers
  • Thin Layer Chromatography
  • Toxicology

Fields of Study

  • Agricultural and Food sciences
  • Medicine

Readers

  • Analytical Chemistry
  • Mathematics or Statistics
  • Toxicology/Environmental Toxicology