Prevention and Treatment of Vesication and Poisoning Caused by Arsenicals.
Abstract
There are two parts to this report: Part I - Protection of Mice against the Lethal Effects of Sodium Arsenite by 2,3 Dimercapto-1-Propane-Sulfonic Acid (DMPS) and Dimercaptosuccinic Acid (DMSA): DMPS and dimercaptosuccinic acid (DMSA) are active orally for the protection of mice against the lethal effects of sodium arsenite. They are effective whether given before or after the administration of NaAsO2. Although D-penicillamine and N-acetyl-DL-penicillamine are useful in the treatment of poisoning by other heavy metals, they are devoid of any protective action under these conditions. Part II - A Quantitative Comparison of a Number of Chelating Agents: A series of polymercapto compounds, some having as many as four mercapto groups per molecule also did not protect against the lethality of NaAsO2. There is extensive experimental and clinical information about DMPS and DMSA available in the Soviet and Chinese literature where these agents are known as Unithiol or Unitiol and succimer, respectively. It would appear that DMPS and DMSA warrant further experimental studies and eventually clinical trials for the treatment of intoxication by arsenic, especially against lewisite gas. These agents have been used in human therapy in the Soviet Union and China. Soviet investigators and West German investigators have recommended that it replace BAL for treatment of heavy metal poisoning.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1981
- Accession Number
- ADA120385
Entities
People
- H. V. Aposhian
Organizations
- University of Arizona