Chemical Carcinogen (Hydrazine et al.) Induced Carcinogenesis of Human Diploid Cells in Vitro

Abstract

Polynuclear hydrocarbons or hydrazine analogues do not have an absolute requirement for binding to DNA in order to elicit a carcinogenic event. Furthermore, PNH like BP enter the nucleus via a lipoprotein complex where the BP is oxygenated and then interacts with the genetic material,(DNA). The adduct formed is 7 beta-BPEDI-dG. Benzamide does not alter the binding of the perceived ultimate carcinogen to dG but eliminates the carcinogenic response. The period of heightened response to the carcinogen appears to be 3 hours into S phase of the cell type. The modifying effect of TPA or Benzamide appears to alter the nuclear non-histone proteins protecting the cellular DNA.

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Document Details

Document Type
Technical Report
Publication Date
Sep 07, 1982
Accession Number
ADA121284

Entities

People

  • G. Milo

Organizations

  • Ohio State University

Tags

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Liquid Chromatography
  • Medical Personnel
  • Nitroso Compounds
  • Organic Chemistry

Fields of Study

  • Chemistry

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular Biology and Genetics
  • Organic Chemistry

Technology Areas

  • Biotechnology