Molecular Characteristics of Membrane Glutamate Receptor-Ionophore Interaction.
Abstract
The excitatory responses produced in mammalian central nervous system neurons and in invertebrate muscles by the action of L-glutamic acid and L-aspartic acid are apparently the result of a glutamate- or aspartate-induced increase in membrane conductance of Na+. In our studies, we have used rat brain synaptosomal and synaptic membrane vesicular preparation to study this process. The synaptosomes and resealed synaptic plasma membrane vesicle preparations from brain tissue are thought to consist largely of presynaptic membrane sacs and of a few postsynaptic membrane vesicles. These plasma membrane fractions apparently retain a high degree of functional and structural integrity. In our laboratory, we have shown that these neuronal plasma membrane subfractions are enriched in glutamic acid binding sites.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 15, 1982
- Accession Number
- ADA121373
Entities
People
- Elias K. Michaelis
- Hsuan Hung Chang
Organizations
- University of Kansas